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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Mitochondrion. 2016 Aug 31;33:84–101. doi: 10.1016/j.mito.2016.08.017

Figure 8. Scheme of potential mitoBKCa mport route and interactions in mitochondria.

Figure 8

Overall the results suggest that the precursor BKCa could be recognized by Tom22 in the outer mitochondrial membrane (OMM) and imported by Tom 40 to reach its final destination in the inner mitochondrial membrane (IMM). At the IMM, mitoBKCa interacts with ADP/ATP translocase (ANT). The interaction could be independent or in combination with known partners of ANT, e.g. the synthasome (ATP synthase and the phosphate carrier, PiC), and implies a new role of mitoBKCa in mitochondrial metabolism. Of note, proteomic analysis (Table 1) points to the possibility that BKCa may also interact with the voltage-dependent anion channel VDAC, the ATP synthase and PiC. VDAC, allows ATP/ADP exchange with the intracellular milieu. IMS, intermembrane space.