Fig. 1.

AXL and MER signaling networks in tumor cells. Schematic representing the major signaling networks activated upon binding of GAS6 with its TAM receptor in tumor cells. Affinity of GAS6 for AXL is higher than that for MER. Tyrosine docking sites in AXL are represented. Diverse adaptor proteins mediate activation of specific signaling pathways, involved in proliferation, migration, and survival. Potential direct and indirect phosphorylation biomarkers of AXL activity (pharmacodynamic markers) are indicated by yellow stars. Crosstalk between AXL and other RTKs is exemplified by the dimerization with EGFR and MET. Signaling implicated in the regulation of the immune response is depicted by blue arrows