Table 3. Odds ratios (95% confidence intervals) of type 2 diabetes associated with tertile levels of plasma lipid measures in men and women separately.*.
T1 | T2 | T3 | P for trend† | Per 1 SD increment | |
---|---|---|---|---|---|
HDL-C | |||||
Men | |||||
Cases/controls | 116/79 | 84/79 | 36/79 | ||
OR (95% CI) | 1.00 | 0.89 (0.54-1.47) | 0.56 (0.29-1.05) | 0.09 | 0.71 (0.53-0.94) |
Women | |||||
Cases/controls | 188/112 | 101/112 | 46/111 | ||
OR (95% CI) | 1.00 | 0.73 (0.44-1.19) | 0.48 (0.26-0.88) | 0.02 | 0.69 (0.53-0.90) |
LDL-C | |||||
Men | |||||
Cases/controls | 78/77 | 71/77 | 66/76 | ||
OR (95% CI) | 1.00 | 1.19 (0.65-2.15) | 0.89 (0.46-2.15) | 0.82 | 1.06 (0.83-1.36) |
Women | |||||
Cases/controls | 111/112 | 107/111 | 103/109 | ||
OR (95% CI) | 1.00 | 0.92 (0.53-1.61) | 0.81 (0.49-1.34) | 0.44 | 1.03 (0.84-1.27) |
TG‡ | |||||
Men | |||||
Cases/controls | 46/79 | 69/79 | 121/78 | ||
OR (95% CI) | 1.00 | 1.09 (0.60-1.98) | 2.25 (1.16-4.36) | 0.007 | 1.61 (1.16-2.24) |
Women | |||||
Cases/controls | 42/115 | 86/111 | 207/109 | ||
OR (95% CI) | 1.00 | 1.82 (0.98-3.39) | 5.03 (2.58-9.81) | <0.001 | 1.85 (1.40-2.44) |
TG/HDL-C ratio§ | |||||
Men | |||||
Cases/controls | 46/79 | 69/79 | 121/78 | ||
OR (95% CI) | 1.00 | 1.01 (0.53-1.90) | 1.98 (1.04-3.79) | 0.01 | 1.61 (1.12-2.34) |
Women | |||||
Cases/controls | 35/112 | 80/112 | 220/111 | ||
OR (95% CI) | 1.00 | 1.68 (0.87-3.26) | 4.98 (2.48-10.0) | <0.001 | 1.80 (1.34-2.39) |
Abbreviations: OR, odds ratio; CI, confidence interval; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TG, triglycerides; TG/HDL-C ratio, the ratio of triglyceride to high-density lipoprotein cholesterol.
Multivariate model adjusted for age at blood taken (continuous), smoking (never, past, current smoker), alcohol intake (never, weekly or daily), physical activity (<0.5, 0.5-3.9, and ≥4 hours/week), education level (no, primary school, secondary or above), history of hypertension (yes, no), fasting status (yes, no), BMI (continuous), plasma concentrations of C-reactive protein (mmol/L) and adiponectin (μg/mL) (both in tertiles).
Linear trend was tested using the median level of each tertile of blood lipid profile.
P for interaction between TG and sex is 0.028.
P for interaction between TG/HDL and sex is 0.017.