Table 3.

Multivariable linear regression analyses of factors independently associated with the cube-root transformed infarct volume

Independent variable	Coefficient (95% CI)	P-value
Unadjusted
WMH lesion burden	0.072 (0.027 to 0.118)	0.002
Model 1*
WMH lesion burden	0.076 (0.031 to 0.120)	0.001
Random glucosea	0.121 (0.014 to 0227)	0.027
Model 2*
WMH lesion burden	0.073 (0.029 to 0.117)	0.002
Random glucosea	0.124 (0.024 to 0.224)	0.016
Admission NIHSSa	0.146 (0.047 to 0.244)	0.004
Preadmission mRS	−0.080 (−0.152 to −0.009)	0.029

^*rtPA use, age, small subcortical infarct subtype as well as history of hypertension and atrial fibrillation were not retained in the model.

^a:cube-root transformed.(15) Note: R²=.115 for the unadjusted analysis, R²=.170 for Model 1, R²=.285 for Model 2.