Table 1.
IBA1 mRNA levels in isolated brain regions of control (sham) and peripheral nerve injury (PNI) groups.
| Brain Region | Sham | PNI | ||
|---|---|---|---|---|
| Ipsilateral | Contralateral | Ipsilateral | Contralateral | |
| mPFC | 0.13 (0.07) | 0.06 (0.03) | 0.12 (0.12) | 0.17 (0.1) |
| NAc | 0.15 (0.04) | 0.32 (0.03) | 0.23 (0.07) | 0.62 (0.03) ***, ##, ϕ |
| BNST | 0.14 (0.08) | 0.14 (0.05) | 0.42 (0.02) | 0.74 (0.06) **, ###, ϕ |
| Amygdala | 0.62 (0.05) | 0.54 (0.06) | 0.71 (0.04) | 1.21 (0.07) ***, ###, ϕϕϕ |
| Hippocampus | 0.31 (0.19) | 0.36 (0.02) | 0.15 (0.05) | 0.12 (0.06) |
| Thalamus | 0.35 (0.07) | 0.28 (0.05) | 0.47 (0.07) | 0.74 (0.04) *, ###, ϕϕ |
| VTA | 0.14 (0.14) | 0.19 (0.07) | 0.42 (0.11) | 0.67 (0.08) # |
Data is expressed as relative expression normalized to beta actin (2^dCT).
Abbreviations: PFC, prefrontal cortex; NAc, nucleus accumbens; BNST, bed nucleus stria terminalis; VTA, ventral tegmental area.
**
=p<0.01,
***
=p<0.001 compared to ipsilateral side of same condition,
#
=p<0.05,
##
=p<0.01,
###
=p<0.001 compared to sham contralateral side,
ϕ
=p<0.05,
ϕϕ
=p<0.01,
ϕϕϕ
=p<0.001 interaction between side and treatment.