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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Addict Biol. 2016 Aug 31;23(1):16–27. doi: 10.1111/adb.12442

Figure 2.

Figure 2

Intra-IL D1 receptor blockade via SCH 23390 (SCH) mediates cued reinstatement. (Note that the y-axis maximum is either 100 or 300 across the different experiments to accommodate the large differences in values.) A–C, The active lever presses and, D–F, the inactive lever presses for each reinstatement test for Experiment 1 are shown. A, Intra-IL microinjections of the D1 receptor antagonist SCH significantly reduced active lever pressing during cued reinstatement compared to vehicle controls (n = 11). B, Intra-IL microinjections of SCH had no effect on active lever presses during cocaine-prime reinstatement (n = 8). C, Intra-IL microinjections of SCH had no effect on active lever pressing during cued + cocaine-prime reinstatement (n = 7). D–F, There were no effects of reinstatement or microinjections on inactive lever presses for any type of reinstatement test. *p < 0.05 compared with extinction baseline. #p < 0.05 compared to vehicle-control group. EXT, extinction baseline.