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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Addict Biol. 2016 Aug 31;23(1):16–27. doi: 10.1111/adb.12442

Figure 5.

Figure 5

Intra-mOFC D2 receptor blockade via sulpiride has no effect on cocaine-seeking behaviors. A–D, The active lever presses and, E–H, inactive lever presses for each reinstatement test for Experiment 4 are shown. A, Intra-mOFC microinjections of sulpiride had no effect on active lever pressing during cued reinstatement compared to vehicle controls (n = 6). B, Although intra-mOFC microinjections of sulpiride had no effect on active lever pressing during cocaine-prime reinstatement, cocaine-prime reinstatement levels were not significantly above the extinction baseline (n = 6). C, Intra-mOFC microinjections of sulpiride had no effect on active lever pressing during cued + cocaine – prime reinstatement (n = 6). D, Due to the low levels of cocaine-prime reinstatement, a separate group of rats underwent only a cocaine-prime reinstatement (n = 6). Intra-mOFC microinjections of sulpiride did not affect active lever pressing when only a cocaine-prime reinstatement test was conducted. E–H, There were no effects of reinstatement or microinjections on inactive lever presses for any type of reinstatement. *p < 0.05 compared with extinction baseline. @p < 0.09 compared with extinction baseline. EXT, extinction baseline.