Table 1.
Summary of the associations between bacterial virulence genes, host genetic polymorphism, and PUD
| Gene | Region | GU | DU |
|---|---|---|---|
| Bacterial virulence | |||
| oipA | Asia and Western | ↑ | |
| babA | Western | ↑ | ↑ |
| cagA | Asian and Western | ↑ | ↑ |
| 12-bp insertion cagA | Asian | ↑ | |
| East-Asian type cagA | Asian | ↑ | ↑ |
| vacA s1m1 | Asian and Western | ↑ | ↑ |
| vacA i1 | Asian and Western | ↑ | ↑ |
| vacA d1 | Asian | ↑ | |
| dupA | Asian | ↑ | |
| intact long-type dupA | Asian | ↑ | |
| iceA1 | Asian and Western | ↑ | ↑ |
| Host genetic factors | |||
| TNF-A-238 G/A | Western | ↑ | ↑ |
| TNF-A-308 G/A | Western | ↑ | ↑ |
| TNF-A-857 T/T | Western | ↑ | ↑ |
| TNF-A-863 A carriers | Asian | ↑ | ↑ |
| TNF-A-1031 C carriers | Asian | ↑ | ↑ |
| IL-1B-31 C/C | Asian | ↑ | ↑ |
| IL-1B-511 T/T | Asian | ↑ | |
| IL-1RN*2/*2 | Asian | ↑ | ↑ |
| IL-6-572 G/G | Asian | ↑ | ↑ |
| IL-8-251 A/A | Asian | ↑ | ↑ |
| IL-10-819 T carriers | South American | ↑ | ↑ |
| IL-10-592 A/A | Asian | ↑ | |
| CYP2C19 URM* | Western | ↑ | ↑ |
| CYP2C19 RM* | Asian | ↑ | ↑ |
| PSCA rs2294008 C carriers | Asian | ↑ | ↑ |
*
URM: Ultra-rapid metabolizers, RM: Rapid metabolizers