Changes in total plaque and VH-IVUS derived plaque constituent areas in sectors subjected to low and non-oscillatory (low time-averaged WSS, low oscillatory WSS) or low and oscillatory (low time-averaged WSS, high oscillatory WSS) WSS. Notably, focal regions of low and oscillatory WSS demonstrated regression of total plaque, fibrous and fibrofatty tissue area, and progression of necrotic core and dense calcium, suggestive of a transformation to a more vulnerable phenotype. Error bars are 95% CIs.