Figure 1.

Histopathological study. A, B. Ngroup. C, D. S14d group. E, F. SN group (osteonecrosis is absent). G, H. SN group (fatty marrow) (A,C,E,G. ×100)(B,D,F,H. ×200). Osteonecrosis was not found in any of the animals in either N or SN group. In St14d group, osteonecrosis was found in 7 of animals (70%). Osteocytes in the stained bone contain achromatic nuclei or empty lacunae, showing typical features of osteonecrosis. Medullary hematopoietic cells around the site of osteonecrosis are interspersed with necrotic and degenerated cells. In SN group, some degree of fatty marrow was found in 2 of 10 animals.