Table 2.
The odds ratios for developing adverse outcomes for each serum marker using raw values adjusted for age and maternal weight.
| P-CS | GDM | LGA | Low APGAR | Macrosomia | PIH | Preterm | SGA | ||
|---|---|---|---|---|---|---|---|---|---|
| Groups | Actual cutoff | 999 (12.9%) | 202 (63.9%) | 80 (4.4%) | 45 (5.3%) | 69 (5.1%) | 65 (4.2%) | 80 (5.1%) | 83 (2.9%) |
| AFP lower (≤ 5th percentile) |
23.44 ng/mL | 1.53 (0.91 - 2.57) | 1.27 (0.69 - 2.32) | 1.42 (0.64 - 3.14) | 2.89 (1.14 - 7.32) * | 1.71 (0.77 - 3.82) | 1.47 (0.60 - 3.59) | 1.08 (0.41 - 2.82) | 1.71 (0.66 - 4.47) |
| AFP upper (≥95th percentile) |
73.11 ng/mL | 1.15 (0.70 - 1.87) | 0.74 (0.33 - 1.65) | 0.62 (0.15 - 2.62) | 0.47 (0.06 - 3.51) | 0.75 (0.18 - 3.18) | 2.42 (0.92 - 6.37) | 0.79 (0.24 - 2.58) | 1.34 (0.56 - 3.22) |
| E3 lower (≤ 5th percentile) |
0.60 ng/mL | 1.44 (0.87 - 2.40) | 1.13 (0.58 - 2.19) | 1.11 (0.42 - 2.90) | 2.43 (0.92 - 6.38) | 1.31 (0.50 - 3.43) | 1.34 (0.46 - 3.89) | 1.57 (0.66 - 3.77) | 0.83 (0.25 - 2.71) |
| E3 upper (≥95th percentile) |
12.60 ng/mL | 4.06 (2.06 - 8.00) * | 2.05 (1.17 - 3.57) * | 0.89 (0.31 - 2.58) | 0.46 (0.06 - 3.37) | 0.76 (0.23 - 2.56) | 3.78 (1.79 - 7.97) * | 1.04 (0.37 - 2.92) | 1.67 (0.70 - 3.98) |
| HCG lower (≤ 5th percentile) |
15.58 IU/mL | 1.00 (0.62 - 1.61) | 0.61 (0.28 - 1.36) | 0.33 (0.08 - 1.40) | 0.39 (0.05 - 2.85) | 0.39 (0.09 - 1.67) | 0.52 (0.12 - 2.21) | 0.68 (0.21 - 2.22) | 0.56 (0.14 - 2.36) |
| HCG upper (≥95th percentile) |
125.90 IU/mL | 3.32 (1.77 - 6.24) * | 2.58 (1.51 - 4.42) * | 0.53 (0.13 - 2.20) | 0.00 (0.00 - Inf) | 0.63 (0.15 - 2.64) | 3.55 (1.59 - 7.90) * | 1.04 (0.37 - 2.93) | 2.09 (0.97 - 4.53) |
| Inhibin lower (≤ 5th percentile) |
92.40 pg/mL | 1.31 (0.74 - 2.29) | 0.85 (0.39 - 1.84) | 0.91 (0.31 - 2.68) | 0.47 (0.06 - 3.54) | 0.00 (0.00 - Inf) | 0.64 (0.15 - 2.77) | 1.23 (0.43 - 3.52) | 2.20 (0.84 - 5.80) |
| Inhibin upper (≥95th percentile) |
397.10 pg/mL | 1.37 (0.79 - 2.38) | 0.51 (0.18 - 1.43) | 0.00 (0.00 - Inf) | 0.00 (0.00 - Inf) | 0.00 (0.00 - Inf) | 1.81 (0.53 - 6.20) | 0.28 (0.04 - 2.07) | 2.26 (0.96 - 5.29) |
| PAPPA lower (≤ 5th percentile) |
1.02 mIU/mL | 1.25 (0.69 - 2.25) | 2.10 (1.03 - 4.26) * | 0.24 (0.03 - 1.79) | 0.49 (0.06 - 3.68) | 0.55 (0.13 - 2.41) | 1.57 (0.44 - 5.57) | 1.96 (0.73 - 5.23) | 1.21 (0.36 - 4.08) |
| PAPPA upper (≥95th percentile) |
10.09 mIU/mL | 4.52 (1.89 - 10.82) * | 2.08 (0.97 - 4.45) | 0.52 (0.07 - 3.94) | 0.63 (0.08 - 4.78) | 0.00 (0.00 - Inf) | 3.50 (0.97 - 12.55) | 0.96 (0.22 - 4.12) | 2.63 (1.05 - 6.57) * |
*: P<0.05. P-CS: primary caesarian section, GDM: gestational diabetes mellitus, LGA: large for gestational age, SGA: small for gestational age, PIH: pregnancy-induced hypertension, PAPPA: pregnancy-associated plasma protein A, AFP: alpha-fetoprotein, HCG: human chorionic gonadotropin, E3: estriol, Inf: infinity.