Figure 1.

HHcy mice are more susceptible to cisplatin-induced AKI. (A) The plasma level of Hcy in mice. (B) The level of serum creatinine (Scr) at day 1 or day 3 after cisplatin injection. *P<0.05 versus control mice; ^#P<0.05 versus mice fed with regular diet. (C) Graphic representation of relative level between serum creatinine and serum Hcy in control and HHcy mice before and after cisplatin injection. (D) Representative micrographs of H&E staining show the morphological injury at day 1 and day 3 after cisplatin injection. (E) Quantification assessment of tubular dilation and atrophy on the basis of H&E staining. Data are expressed as mean±SD, n=5. *P<0.05 versus control, ^#P<0.05 versus mice fed with regular diet mice.