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. 2017 Feb 9;8(3):345–353. doi: 10.7150/jca.16607

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Twist1 upregulates DNA damage repair (DDR). (A) 2 h after 6 Gy ionizing radiation, control or Twist1+/Twist1- cells were fixed and H2AX and DAPI staining was performed by immunofluorescence. Scale bar, 20 um. (B) Control or Twist1+/Twist1-cells were cultured under hypoxia and treated with 6 Gy ionizing radiation. 2 h after irradiation, cells were lysed and γH2AX was detected by western blot. (C) and (D) Images (C) and data quantification (D) of singer cell comet assays of control or Twist1+/Twist1- SiHa cells at the indicated time points after 6 Gy ionizing radiation. N=25 cells per group. The asterisk (*) indicates a significant decrease (p<0.05) in 16 comet tail moment and the asterisk (**) indicates a significant (p<0.01) increase.