Figure 5.
Twist1 correlates with HIF-1α protein levels and poor clinical outcome in human cervical cancer. (A) Immunohistochemical staining of Twist1 and HIF-1α in representative cancer specimens on cervical cancer tissue microarrays. Brown staining indicates positive immunoreactivity. Scale bar, 25um. (B) Correlation between Twist1 and HIF-1α protein levels in human cervical tumors. Statistical significance was determined by χ2 test. R is the correlation coefficient. (C) Kaplan-Meier curves show the local relapse-free survival of patients with high or low expression of Twist1 in their cervical tumors. Statistical significance was determined by a log-rank test. (D) The mechanic model of regulation of radiosensitivity and DDR by Twist1.