Figure 1.

T regulatory cells (Treg) from B−/− mice are more effective at suppressing spontaneous autoimmune thyroiditis (SAT) than Treg from wild-type (WT) mice. T cells from CD28−/−B−/− Non-obese diabetic (NOD).H-2h4 mice were cultured with or without Treg from WT or B−/− NOD.H-2h4 mice. TCR−/− NOD.H-2h4 recipients were given 5 × 10⁶ cultured T cells, and were given NaI in their drinking water. The no transfer group did not receive T cells. Thyroids were removed 8 weeks later. ** p < 0.01; *** p < 0.001, n.s., not significant. Results are the mean SAT severity scores from individual recipient mice. See [63] for additional details.