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. 2017 Jan 26;6(2):13. doi: 10.3390/jcm6020013

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Repopulating Treg have reduced suppressive function compared to endogenous Treg. Treg were depleted by injection of anti-CD25 (Foxp3-GFP.NOD.H-2h4 mice) or diphtheria toxin (DT) (Foxp3-DTR NOD.H-2h4 mice. Treg were allowed to repopulate the spleen, and repopulating or control (endogenous) Treg were cultured with naïve T cells from CD28−/−B−/− NOD.H-2h4 mice. Groups of TCR−/− NOD.H-2h4 recipient mice were given T cells cultured with or without Treg, and all mice were given NaI water for 8 weeks. (A): n = 11 mice/group; (B): n = 9 mice/group. ** p < 0.01; *** p < 0.001. Results are mean SAT severity scores from groups of 9–11 recipients ± SEM. Additional details are in [63].