Figure 5.

Dynamic release of glucose-stimulated insulin secretion in E6-infected islets. Fifty hand-picked and size-matched islets from three donors were infected with E6/91 and E6/12. Mock-infected islets were left as a negative control. On day three after infection, the islets were perifused with glucose (1.67 mmol/L, 16.7 mmol/L, and 1.67 mmol/L). Fractions were collected at six-minute intervals and the secreted insulin was measured by enzyme-linked immunosorbent assay (ELISA). Data are presented as means ± SD and are based on observations from at least three donors. * p < 0.05 between groups (minutes 42 to 102).