Table 1.

Expression profile of inflammasomes and NLR genes in the rat brain in response to lipopolysaccharides (LPS), with and without morphine tolerance.

	morphine-tolerant + saline/placebo control + saline		placebo control + LPS/placebo control + saline		morphine-tolerant + LPS/morphine-tolerant + saline
Gene	Fold Change	p-value *	Fold Change **	p-value *	Fold Change **	p-value *
Card6	−1.2347	0.078926	−1.5292	0.004159	−1.714	0.017499
Casp1	1.1505	0.299299	1.2132	0.276593	1.2764	0.02969
Casp12	1.0972	0.462347	1.5422	0.003614	1.4249	0.092085
Casp8	−1.0402	0.612597	−1.1363	0.391056	−1.2652	0.139999
Naip2	−1.4483	0.067329	−1.1031	0.619799	−1.2316	0.25758
Nlrp12	−1.6504	0.674422	−7.31	0.002731	−4.5124	0.025372
Nlrp5	1.494	0.054876	1.274	0.20786	1.2819	0.027352
Nlrc4	1.0028	0.915792	1.1349	0.159712	1.1003	0.445719
Nlrp1a	−1.0898	0.470844	−1.2027	0.001147	−1.3308	0.1379
Nlrp3	1.3773	0.134647	1.5114	0.054565	1.3956	0.02407
Nlrp6	1.205	0.420019	−1.6225	0.358997	1.0293	0.784547
Nlrx1	−1.1574	0.24832	−1.1494	0.191026	1.039	0.679959
Nod2	−1.6257	0.650152	1.0901	0.811946	1.2826	0.50395
Pycard	−1.0575	0.610143	−1.0285	0.797363	−1.2363	0.030115

* For p-value, letters in red mean p < 0.05. ** For Fold Change, letters in red mean fold change >2 and letters in blue mean the fold change <−2. For the color lines, : 6–10 fold decrease; : 2–5 fold decrease; : <2 fold; : 2–5 fold increase; : 6–10 fold increase; : 11–30 fold increase; : 31–50 fold increase.