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. 2017 Feb 6;7(2):14. doi: 10.3390/brainsci7020014

Table 2.

Expression profile of inflammasome-related downstream signaling genes in the rat brain in response to lipopolysaccharides (LPS), with and without morphine tolerance. Full name of the genes were provided in Appendix Table A1.

morphine-tolerant + saline/placebo control + saline placebo control + LPS/placebo control + saline morphine-tolerant + LPS/morphine-tolerant + saline
Gene Fold Change p-value * Fold Change ** p-value * Fold Change ** p-value *
Bcl2 1.0469 0.863233 1.0586 0.845254 1.2398 0.339246
Bcl2l1 −1.1256 0.01111 1.0572 0.476643 −1.0291 0.671184
Birc2 1.0509 0.586337 −1.0281 0.622487 1.0699 0.531417
Birc3 1.0648 0.587513 20.9356 0.011065 21.5025 0.001873
Cflar 1.0226 0.697346 1.3021 0.004748 1.2155 0.140978
Chuk 1.1867 0.119108 −1.0233 0.754891 1.1593 0.073058
Ciita −1.0617 0.750879 1.0619 0.873363 1.4678 0.39646
Ctsb −1.0009 0.978499 −1.0656 0.617885 −1.1046 0.493204
Fadd −1.1261 0.258884 1.1235 0.252486 1.0306 0.71174
Hsp90aa1 1.2774 0.114349 1.0391 0.743375 1.189 0.149024
Hsp90ab1 1.0752 0.376876 −1.0968 0.305427 1.1579 0.18515
Ikbkb 1.0718 0.550623 −1.0011 0.962992 1.1799 0.201955
Ikbkg 1.0924 0.324904 −1.0402 0.492725 1.1419 0.079202
Irak1 1.1549 0.062648 1.0287 0.755395 1.2213 0.242955
Map3k7 −1.2495 0.002404 −1.1008 0.434596 −1.2497 0.114056
Map3k7ip1 −1.0335 0.664499 −1.1151 0.369226 1.02 0.864431
Map3k7ip2 −1.2869 0.000867 −1.1169 0.456355 −1.3427 0.007785
Mapk1 −1.0527 0.468581 −1.0887 0.159097 1.0316 0.724595
Mapk11 −1.0673 0.530192 −1.0706 0.578016 −1.0633 0.571223
Mapk12 1.1424 0.420684 1.1889 0.372287 −1.0255 0.780819
Mapk13 −1.1629 0.924422 −1.5423 0.355826 1.0504 0.651078
Mapk14 1.0018 0.940725 −1.0318 0.81795 1.0335 0.709962
Mapk3 −1.1294 0.224192 −1.121 0.372958 −1.0495 0.76638
Mapk8 1.0383 0.883566 −1.0215 0.798267 1.0037 0.911563
Mapk9 −1.1252 0.03886 −1.0075 0.87718 −1.0805 0.288977
Mefv 1.2572 0.278807 1.2582 0.463496 1.9192 0.028283
Myd88 1.0211 0.791137 1.0103 0.917416 1.2185 0.03802
Nfkb1 1.1098 0.279116 1.2919 0.089881 1.3323 0.033357
Nfkbia −1.0294 0.835021 3.885 0.001215 3.3744 0.001348
Nfkbib −1.1473 0.330475 −1.0153 0.762037 −1.1167 0.643504
P2rx7 −1.1586 0.428492 1.0742 0.625549 1.0578 0.661519
Panx1 −1.076 0.275575 1.1455 0.406863 1.1101 0.334734
Pea15a −1.0943 0.291531 −1.043 0.625202 −1.0802 0.492135
Pstpip1 −1.1041 0.527175 −1.1018 0.680263 −1.0232 0.87342
Ptgs2 −1.08 0.499364 1.5126 0.000571 1.1762 0.323717
Rage 1.0729 0.478448 −1.1273 0.17423 1.1854 0.16574
Rela 1.0171 0.804744 1.1801 0.417806 1.2504 0.106174
Ripk2 −1.1057 0.237762 1.2913 0.028006 1.1199 0.389288
Sugt1 1.0063 0.918273 −1.1023 0.519396 −1.1264 0.106262
Tirap −1.3098 0.094434 −1.0971 0.535721 1.0809 0.374146
Hsp90b1 1.0475 0.680071 −1.0334 0.69801 −1.0877 0.314466
Traf6 −1.0344 0.915204 −1.0171 0.943304 1.0988 0.437323
Txnip −1.0761 0.70951 −1.0718 0.699702 −1.0187 0.789181
Xiap 1.0572 0.503462 −1.0558 0.471524 1.0089 0.93573

* For p-value, letters in red mean p < 0.05. ** For Fold Change, letters in red mean fold change >2 and letters in blue mean the fold change <−2. For the color line, Inline graphic: 6–10 fold decrease; Inline graphic: 2–5 fold decrease; Inline graphic: <2 fold; Inline graphic: 2–5 fold increase; Inline graphic: 6–10 fold increase; Inline graphic: 11–30 fold increase; Inline graphic: 31–50 fold increase.