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. 2017 Feb 15;7(2):20. doi: 10.3390/brainsci7020020

Table 12.

GHK and Genes Associated with Neurons.

UP Gene Title Percent Change
1 opioid receptor, mu 1, OPRM1 1294
2 tumor protein p73, TP73 938
3 potassium voltage-gated channel, Shal-related subfamily, member 1, KCND1 845
4 solute carrier family 8 (sodium/calcium exchanger), member 2, SLC8A2 737
5 contactin associated protein-like 2, CNTNAP2 581
6 stathmin-like 3, STMN3 500
7 latrophilin 3, LPHN3 494
8 angiopoietin 1, ANGPT1 487
9 synapsin III, SYN3 478
10 dipeptidyl-peptidase 6, DPP6 448
11 somatostatin receptor 2, SSTR2 442
12 G protein-coupled receptor, family C, group 5, member B, GPRC5B 431
13 sodium channel, voltage-gated, type III, alpha subunit, SCN3A 423
14 smoothened homolog (Drosophila), SMO 415
15 tryptophan hydroxylase 1, TPH1 409
16 caspase 8, apoptosis-related cysteine peptidase, CASP8 399
17 gamma-aminobutyric acid (GABA) A receptor, alpha 5 /// gamma-aminobutyric acid receptor subunit alpha-5-like, GABRA5 /// LOC100509612 392
18 transcription factor 7 (T-cell specific, HMG-box), TCF7 372
19 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6, SLC17A6 369
20 doublecortin-like kinase 1, DCLK1 365
21 p21 protein (Cdc42/Rac)-activated kinase 1, PAK1 363
22 neurogenic differentiation 4, NEUROD4 362
23 zinc finger protein 335, ZNF335 358
24 wingless-type MMTV integration site family, member 3, WNT3 352
25 ADAM metallopeptidase domain 8, ADAM8 352
26 neuropeptide Y, NPY 346
27 potassium voltage-gated channel, Shaw-related subfamily, member 3, KCNC3 332
28 EPH receptor B1, EPHB1 330
29 LIM domain kinase 1, LIMK1 322
30 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila), MLL 318
31 growth associated protein 43, GAP43 305
32 FBJ murine osteosarcoma viral oncogene homolog, FOS 305
33 sal-like 1 (Drosophila), SALL1 302
34 synovial sarcoma, X breakpoint 2 /// synovial sarcoma, X breakpoint 2B, SSX2 /// SSX2B 301
35 inositol 1,4,5-triphosphate receptor, type 3, ITPR3 298
36 bone morphogenetic protein receptor, type IB, BMPR1B 298
37 synuclein, gamma (breast cancer-specific protein 1), SNCG 292
38 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, CACNA1A 286
39 capping protein (actin filament) muscle Z-line, beta, CAPZB 285
40 plexin C1, PLXNC1 282
41 nuclear factor I/B, NFIB 279
42 islet amyloid polypeptide, IAPP 276
43 nephroblastoma overexpressed gene, NOV 275
44 hyperpolarization activated cyclic nucleotide-gated potassium channel 4, HCN4 269
45 calsyntenin 2, CLSTN2 268
46 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1, KCNN1 266
47 sodium channel, voltage-gated, type II, alpha subunit, SCN2A 264
48 neuroligin 1, NLGN1 261
49 ELKS/RAB6-interacting/CAST family member 2, ERC2 261
50 scratch homolog 1, zinc finger protein (Drosophila), SCRT1 252
51 low density lipoprotein receptor-related protein 1, LRP1 249
52 hypothetical protein LOC728392 /// NLR family, pyrin domain containing 1, LOC728392 /// NLRP1 249
53 opiate receptor-like 1, OPRL1 246
54 myosin, heavy chain 14, non-muscle, MYH14 243
55 nitric oxide synthase 1 (neuronal), NOS1 240
56 wingless-type MMTV integration site family, member 2B, WNT2B 238
57 glutamate receptor, metabotropic 1, GRM1 231
58 glutamate receptor interacting protein 1, GRIP1 230
59 myelin associated glycoprotein, MAG 229
60 chemokine (C-C motif) ligand 3 /// chemokine (C-C motif) ligand 3-like 1 /// chemokine (C-C motif) ligand 3-like 3, CCL3 /// CCL3L1 /// CCL3L3 228
61 family with sequence similarity 162, member A, FAM162A 228
62 sphingosine-1-phosphate receptor 5, S1PR5 227
63 protein tyrosine phosphatase, receptor type, R, PTPRR 225
64 IKAROS family zinc finger 1 (Ikaros), IKZF1 225
65 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3, KCNN3 221
66 solute carrier family 18 (vesicular monoamine), member 2, SLC18A2 219
67 glutamate receptor, ionotropic, N-methyl d-aspartate 1, GRIN1 216
68 v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian), SRC 216
69 jagged 1, JAG1 215
70 adenylate cyclase activating polypeptide 1 (pituitary), ADCYAP1 215
71 ATPase, Ca++ transporting, plasma membrane 2, ATP2B2 214
72 tripartite motif-containing 2, TRIM2 213
73 netrin 1, NTN1 212
74 paired related homeobox 1, PRRX1 209
75 purinergic receptor P2X, ligand-gated ion channel, 3, P2RX3 207
76 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein, ID4 203
77 solute carrier family 5 (choline transporter), member 7, SLC5A7 202
78 empty spiracles homeobox 1, EMX1 202
79 muscle, skeletal, receptor tyrosine kinase, MUSK 200
80 GATA binding protein 2, GATA2 193
81 cadherin 13, H-cadherin (heart), CDH13 192
82 Rho/Rac guanine nucleotide exchange factor (GEF) 2, ARHGEF2 191
83 anaplastic lymphoma receptor tyrosine kinase, ALK 191
84 cholecystokinin A receptor, CCKAR 190
85 GLI family zinc finger 2, GLI2 183
86 cholinergic receptor, nicotinic, beta 1 (muscle), CHRNB1 182
87 NK2 homeobox 2, NKX2-2 181
88 purinergic receptor P2X, ligand-gated ion channel, 4, P2RX4 180
89 gamma-aminobutyric acid (GABA) receptor, rho 2, GABRR2 179
90 PDZ and LIM domain 5, PDLIM5 177
91 plasminogen activator, urokinase, PLAU 172
92 cannabinoid receptor 1 (brain), CNR1 172
93 chondrolectin, CHODL 172
94 neurexin 2, NRXN2 171
95 parkinson protein 2, E3 ubiquitin protein ligase (parkin), PARK2 169
96 calcium channel, voltage-dependent, L type, alpha 1F subunit, CACNA1F 168
97 neuregulin 1, NRG1 164
98 zinc finger protein 536, ZNF536 162
99 endothelin 3, EDN3 161
100 paired box 7, PAX7 161
101 calcium/calmodulin-dependent protein kinase II beta, CAMK2B 161
102 solute carrier family 30 (zinc transporter), member 3, SLC30A3 160
103 ciliary neurotrophic factor /// zinc finger protein 91 homolog (mouse) /// ZFP91-CNTF readthrough transcript, CNTF /// ZFP91 /// ZFP91-CNTF 159
104 calcium channel, voltage-dependent, T type, alpha 1I subunit, CACNA1I 156
105 membrane associated guanylate kinase, WW and PDZ domain containing 2, MAGI2 155
106 sigma non-opioid intracellular receptor 1, SIGMAR1 155
107 leptin, LEP 152
108 microtubule-associated protein tau, MAPT 150
109 erythropoietin receptor, EPOR 147
110 frizzled homolog 8 (Drosophila), FZD8 147
111 nuclear mitotic apparatus protein 1, NUMA1 147
112 ninjurin 2, NINJ2 144
113 probable transcription factor PML-like /// promyelocytic leukemia, LOC652346 /// PML 144
114 fasciculation and elongation protein zeta 1 (zygin I), FEZ1 143
115 ribonucleotide reductase M1, RRM1 142
116 retinoic acid receptor, beta, RARB 142
117 metallothionein 3, MT3 142
118 vascular endothelial growth factor A, VEGFA 141
119 glycoprotein M6A, GPM6A 140
120 runt-related transcription factor 1, RUNX1 136
121 cholinergic receptor, nicotinic, delta, CHRND 135
122 testis specific, 10, TSGA10 135
123 growth hormone secretagogue receptor, GHSR 135
124 guanine nucleotide binding protein (G protein), beta polypeptide 3, GNB3 134
125 glycine receptor, beta, GLRB 132
126 runt-related transcription factor 1; translocated to, 1 (cyclin D-related), RUNX1T1 131
127 synaptotagmin V, SYT5 131
128 bridging integrator 1, BIN1 130
129 general transcription factor IIi, GTF2I 128
130 mitogen-activated protein kinase kinase 7, MAP2K7 127
131 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha, PPARGC1A 126
132 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian), ERBB4 125
133 retinoic acid receptor, alpha, RARA 123
134 baculoviral IAP repeat-containing protein 1-like /// NLR family, apoptosis inhibitory protein, LOC100510692 /// NAIP 123
135 myosin VA (heavy chain 12, myoxin), MYO5A 122
136 heat shock protein 90kDa alpha (cytosolic), class B member 1, HSP90AB1 121
137 voltage-dependent anion channel 1, VDAC1 120
138 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase), PTGS2 120
139 spectrin, beta, non-erythrocytic 1, SPTBN1 120
140 tubulin, beta 2A /// tubulin, beta 2B, TUBB2A /// TUBB2B 119
141 misshapen-like kinase 1, MINK1 119
142 neural cell adhesion molecule 1, NCAM1 119
143 kelch-like 1 (Drosophila), KLHL1 119
144 sperm associated antigen 9, SPAG9 118
145 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone), GNRH1 116
146 cholinergic receptor, nicotinic, beta 3, CHRNB3 115
147 neuralized homolog (Drosophila), NEURL 115
148 SRY (sex determining region Y)-box 14, SOX14 115
149 purinergic receptor P2X, ligand-gated ion channel, 1, P2RX1 112
150 transcription factor 4, TCF4 112
151 lysozyme, LYZ 111
152 MYC associated factor X, MAX 111
153 synaptojanin 1, SYNJ1 108
154 ret proto-oncogene, RET 108
155 cadherin 2, type 1, N-cadherin (neuronal), CDH2 108
156 AXL receptor tyrosine kinase, AXL 108
157 ataxia telangiectasia mutated, ATM 107
158 parvalbumin, PVALB 107
159 glyceraldehyde-3-phosphate dehydrogenase, GAPDH 107
160 Rap guanine nucleotide exchange factor (GEF) 1, RAPGEF1 106
161 protein kinase C, gamma, PRKCG 106
162 neurofibromin 2 (merlin), NF2 105
163 serrate RNA effector molecule homolog (Arabidopsis), SRRT 105
164 syntaxin 3, STX3 105
165 X-box binding protein 1, XBP1 104
166 potassium large conductance calcium-activated channel, subfamily M, beta member 2, KCNMB2 104
167 chemokine (C-X3-C motif) receptor 1, CX3CR1 104
168 aldehyde dehydrogenase 1 family, member A2, ALDH1A2 103
169 drebrin 1, DBN1 103
170 UDP glycosyltransferase 8, UGT8 103
171 achaete-scute complex homolog 1 (Drosophila), ASCL1 103
172 POU class 4 homeobox 3, POU4F3 102
173 neurofibromin 1, NF1 102
174 steroidogenic acute regulatory protein, STAR 101
175 histamine receptor H3, HRH3 101
176 nuclear receptor subfamily 2, group F, member 6, NR2F6 100
177 transforming growth factor, beta 1, TGFB1 100
178 homeobox D3, HOXD3 100
DOWN Gene Title Percent Change
81 5-hydroxytryptamine (serotonin) receptor 3A, HTR3A −100
82 neuroligin 3, NLGN3 −101
83 aquaporin 1 (Colton blood group), AQP1 −101
84 SH3 and multiple ankyrin repeat domains 2, SHANK2 −102
85 neurochondrin, NCDN −102
86 astrotactin 1, ASTN1 −102
87 mitogen-activated protein kinase 8 interacting protein 2, MAPK8IP2 −103
88 limbic system-associated membrane protein, LSAMP −103
89 calcium binding protein 1, CABP1 −106
90 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12), ITGB1 −107
91 discs, large (Drosophila) homolog-associated protein 2, DLGAP2 −108
92 doublecortin, DCX −108
93 colony stimulating factor 3 (granulocyte), CSF3 −108
94 advanced glycosylation end product-specific receptor, AGER −108
95 corticotropin releasing hormone receptor 1, CRHR1 −109
96 neuropeptides B/W receptor 2, NPBWR2 −109
97 even-skipped homeobox 1, EVX1 −110
98 retinoid X receptor, gamma, RXRG −110
99 cytoplasmic polyadenylation element binding protein 3, CPEB3 −112
100 alpha tubulin acetyltransferase 1, ATAT1 −113
101 paralemmin, PALM −115
102 tumor necrosis factor, TNF −115
103 fatty acid binding protein 7, brain, FABP7 −118
104 olfactory marker protein, OMP −118
105 Amphiregulin, AREG −118
106 opioid receptor, kappa 1, OPRK1 −119
107 calbindin 2, CALB2 −119
108 phosphodiesterase 10A, PDE10A −121
109 early growth response 1, EGR1 −121
110 cell cycle exit and neuronal differentiation 1, CEND1 −123
111 5-hydroxytryptamine (serotonin) receptor 3B, HTR3B −123
112 synaptosomal-associated protein, 23kDa, SNAP23 −123
113 sodium channel, voltage-gated, type XI, alpha subunit, SCN11A −124
114 growth arrest-specific 7, GAS7 −124
115 contactin 1, CNTN1 −125
116 neuroligin 4, X-linked, NLGN4X −128
117 gamma-aminobutyric acid (GABA) A receptor, alpha 1, GABRA1 −130
118 leucine zipper, putative tumor suppressor 1, LZTS1 −130
119 mesenchyme homeobox 2, MEOX2 −131
120 TYRO3 protein tyrosine kinase, TYRO3 −131
121 synaptophysin, SYP −132
122 coiled-coil domain containing 64, CCDC64 −132
123 leucine-rich, glioma inactivated 1, LGI1 −132
124 nerve growth factor receptor, NGFR −132
125 cholinergic receptor, nicotinic, beta 4, CHRNB4 −135
126 5-hydroxytryptamine (serotonin) receptor 2A, HTR2A −135
127 myocyte enhancer factor 2C, MEF2C −138
128 cholinergic receptor, nicotinic, alpha 4, CHRNA4 −139
129 prodynorphin, PDYN −142
130 discs, large homolog 2 (Drosophila), DLG2 −142
131 neurexin 1, NRXN1 −144
132 secretin, SCT −148
133 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, SERPINF1 −148
134 tachykinin receptor 3, TACR3 −150
135 Ras homolog enriched in brain, RHEB −150
136 PARK2 co-regulated, PACRG −153
137 glutamate receptor, ionotropic, kainate 5, GRIK5 −159
138 bone morphogenetic protein 2, BMP2 −159
139 choline O-acetyltransferase, CHAT −160
140 sodium channel, voltage-gated, type I, alpha subunit, SCN1A −162
141 TOX high mobility group box family member 3, TOX3 −163
142 gastric inhibitory polypeptide, GIP −164
143 corticotropin releasing hormone receptor 2, CRHR2 −165
144 kinesin family member 1A, KIF1A −165
145 RAB35, member RAS oncogene family, RAB35 −166
146 protein kinase C, theta, PRKCQ −167
147 cell adhesion molecule with homology to L1CAM (close homolog of L1), CHL1 −171
148 unc-51-like kinase 4 (C. elegans), ULK4 −172
149 wingless-type MMTV integration site family, member 4, WNT4 −175
150 thyroid stimulating hormone receptor, TSHR −175
151 potassium voltage-gated channel, Shal-related subfamily, member 3, KCND3 −175
152 contactin 2 (axonal), CNTN2 −180
153 glutamate receptor, ionotropic, N-methyl D-aspartate 2A, GRIN2A −180
154 fibronectin leucine rich transmembrane protein 1, FLRT1 −183
155 gamma-aminobutyric acid (GABA) A receptor, gamma 3, GABRG3 −186
156 calcium/calmodulin-dependent protein kinase IG, CAMK1G −187
157 interleukin 6 receptor, IL6R −190
158 calsyntenin 3, CLSTN3 −191
159 vesicle-associated membrane protein 1 (synaptobrevin 1), VAMP1 −193
160 promyelocytic leukemia, PML −196
161 ATPase, H+ transporting, lysosomal accessory protein 2, ATP6AP2 −209
162 mitogen-activated protein kinase 8 interacting protein 3, MAPK8IP3 −209
163 estrogen receptor 2 (ER beta), ESR2 −216
164 cytochrome b-245, beta polypeptide, CYBB −217
165 purinergic receptor P2Y, G-protein coupled, 11 /// PPAN-P2RY11 readthrough, P2RY11 /// PPAN-P2RY11 −219
166 sonic hedgehog, SHH −220
167 growth differentiation factor 11, GDF11 −221
168 protein tyrosine phosphatase, receptor type, D, PTPRD −221
169 ELK1, member of ETS oncogene family, ELK1 −224
170 regulating synaptic membrane exocytosis 1, RIMS1 −225
171 hairy/enhancer-of-split related with YRPW motif-like, HEYL −228
172 neurotrophic tyrosine kinase, receptor, type 3, NTRK3 −230
173 potassium voltage-gated channel, Shab-related subfamily, member 2, KCNB2 −233
174 regulator of G-protein signaling 6, RGS6 −235
175 glycine receptor, alpha 3, GLRA3 −235
176 potassium voltage-gated channel, shaker-related subfamily, beta member 1, KCNAB1 −235
177 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1, GNAT1 −242
178 proprotein convertase subtilisin/kexin type 2, PCSK2 −242
179 nerve growth factor (beta polypeptide), NGF −243
180 corticotropin releasing hormone, CRH −243
181 laminin, alpha 1, LAMA1 −245
182 cyclic nucleotide gated channel alpha 3, CNGA3 −249
183 glutamate receptor, ionotropic, kainate 1, GRIK1 −254
184 lin-28 homolog A (C. elegans), LIN28A −259
185 empty spiracles homeobox 2, EMX2 −260
186 cyclin-dependent kinase 5, regulatory subunit 1 (p35), CDK5R1 −260
187 agrin, AGRN −264
188 T-box, brain, 1, TBR1 −272
189 stathmin-like 2, STMN2 −274
190 microcephalin 1, MCPH1 −275
191 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D), ELAVL4 −282
192 mitogen-activated protein kinase 8 interacting protein 1, MAPK8IP1 −289
193 calcium channel, voltage-dependent, N type, alpha 1B subunit, CACNA1B −290
194 FEZ family zinc finger 2, FEZF2 −295
195 dopamine receptor D4, DRD4 −296
196 zinc finger E-box binding homeobox 1, ZEB1 −300
197 T-cell leukemia homeobox 1, TLX1 −311
198 sterile alpha motif domain containing 4A, SAMD4A −315
199 opioid binding protein/cell adhesion molecule-like, OPCML −333
200 fibroblast growth factor receptor 2, FGFR2 −337
201 SRY (sex determining region Y)-box 1, SOX1 −337
202 neurogenin 1, NEUROG1 −345
203 PTK2B protein tyrosine kinase 2 beta, PTK2B −348
204 somatostatin receptor 5, SSTR5 −353
205 myelin basic protein, MBP −361
206 EPH receptor A7, EPHA7 −365
207 G protein-coupled receptor 173, GPR173 −373
208 S100 calcium binding protein A5, S100A5 −374
209 acyl-CoA synthetase long-chain family member 6, ACSL6 −384
210 family with sequence similarity 107, member A, FAM107A −407
211 Kv channel interacting protein 1, KCNIP1 −413
212 Fas apoptotic inhibitory molecule 2, FAIM2 −416
213 bradykinin receptor B1, BDKRB1 −426
214 discs, large homolog 4 (Drosophila), DLG4 −452
215 adenylate cyclase 10 (soluble), ADCY10 −460
216 cyclin-dependent kinase 5, regulatory subunit 2 (p39), CDK5R2 −481
217 EPH receptor A3, EPHA3 −485
218 phosphodiesterase 1A, calmodulin-dependent, PDE1A −485
219 chemokine (C-X-C motif) receptor 4, CXCR4 −496
220 membrane metallo-endopeptidase, MME −540
221 paired-like homeodomain 3, PITX3 −541
222 notch 3, NOTCH3 −547
223 discs, large (Drosophila) homolog-associated protein 1, DLGAP1 −547
224 slit homolog 1 (Drosophila), SLIT1 −553
225 bassoon (presynaptic cytomatrix protein), BSN −563
226 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila), CELSR1 −647
227 calcium channel, voltage-dependent, beta 4 subunit, CACNB4 −672
228 necdin homolog (mouse), NDN −729
229 endothelin receptor type B, EDNRB −768
230 cholinergic receptor, muscarinic 2, CHRM2 −1049