Table 3.
Summary of changes in biomarkers in response to NP exposure showing the main contrast to the respective unexposed controls.
| NP Type | Cell Model | LDH | Caspase-3 | IL-6 | IL-8 | MCP-1 | Epithelial Integrity |
|---|---|---|---|---|---|---|---|
| Ag | CF HBE | + | = | = | + | − | = |
| Normal HBE | (−) | = | = | (+) | = | = | |
| BEAS-2B | − | = | = | = | = | = | |
| C | CF HBE | + | = | = | = | = | = |
| Normal HBE | = | = | + | + | (+) | = | |
| BEAS-2B | + * | = | + | + | + | = |
+: significant (p < 0.05) increase, in parenthesis not significant (p > 0.05). −: significant (p < 0.05) decrease, in parenthesis not significant (p > 0.05). = no response. *: values of control cultures were also high; NP: Nanoparticles; LDH: Lactate dehydrogenase; IL: Interleukin; MCP: Monocyte chemotactic protein; Ag: Silver; C: Carbon; CF: Cystic fibrosis; HBE: Human bronchial epithelia; BEAS-2B: Human bronchial epithelial cell line.