Figure 1.

Replication-coupled chromatin assembly. (A) Scheme of the eukaryotic replisome progression complex together with the replication processivity factor proliferating cell nuclear antigen (PCNA), its loader replication factor C (RFC), the single-strand (ss)DNA binding protein replication protein A (RPA) and the replicative polymerases. Only the yeast names are indicated here, though all factors are conserved in human [22]; (B) Histone modifiers, histone chaperones and histone deposition factors in yeast (left) and human (right). Dashed lines indicate physical interactions. See text for details.