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. 2017 Jan 27;8(2):54. doi: 10.3390/genes8020054

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic representation of possible mechanism involved in origin-independent replication initiation by inducible stable DNA replication/break-induced replication (iSDR/BIR) or constitutive stable DNA replication/transcription-initiated replication (cSDR/TIR). Invading and newly synthesized DNA (red), RNA (green), and helicases (green circle) are indicated. Dashed arrows indicate putative scenarios for TIR-dependent replication initiation. Note that none of these scenarios have been experimentally verified. See text for more details. DSB: double-strand break.