Figure 3.

Interaction of p58_C with a DNA template primed by RNA. (A) p58_C specifically recognizes the DNA:RNA junction at the primer 5′-end containing the triphosphate. The p58_C surface is represented by the vacuum electrostatic potential at 20% transparency; (B) mechanism of p58_C specificity to a purine at the initiation site. The hydrogen bond is depicted by dashed blue line; (C) DNA template bends between T3 and T4. All parts of the figure were drawn using the coordinates of the p58_C/DNA:RNA complex (PDB ID 5F0Q).