Table 1.
List of the high-resolution structures of the human primosome and its domains.
| PDB ID | Resolution, (Å) | Protein Construct | Structural Metals | Cofactors | Deposition Date | Reference |
|---|---|---|---|---|---|---|
| 3L9Q | 1.7 | p58(272–464) | 4Fe-4S | 5 January 2010 | [21] | |
| 3Q36 | 2.5 | p58(266–457) | 4Fe-4S | 21 December 2010 | [22] | |
| 4BPU | 2.7 | p49 a/p58(1–253) | Zn | 28 May 2013 | [16] | |
| 4BPW | 3.0 | p49 a/p58(1–253) | Zn | UTP, Mg | 28 May 2013 | [16] |
| 4BPX | 3.4 | p49 a/p58(19–253) b/p180(1445–1462) | Zn | 28 May 2013 | [16] | |
| 4LIK | 1.7 | p49(1–390) c | Zn | 2 July 2013 | [23] | |
| 4LIL | 2.6 | p49(1–390) c | Zn | UTP, Mn | 2 July 2013 | [23] |
| 4MHQ | 2.2 | p49 | Zn | 30 August 2013 | ||
| 4QCL | 2.2 | p180(335–1257) d | Zn | DNA:RNA, dCTP, Mg | 12 May 2014 | [17] |
| 4Q5V | 2.52 | p180(335–1257) d | DNA:RNA, aphidicolin | 17 April 2014 | [17] | |
| 4RR2 | 2.65 | p49/p58 | Zn, 4Fe-4S | 5 November 2014 | [18] | |
| 4Y97 | 2.51 | p180(1265–1444)/p70 | Zn | 17 February 2015 | [19] | |
| 5DQO | 2.3 | p58(272–464) e | 4Fe-4S | 15 September 2015 | ||
| 5EXR | 3.6 | p49/p58/p180 d/p70 | Zn, 4Fe-4S | 24 November 2015 | [13] | |
| 5F0Q | 2.2 | p58(266–456) | 4Fe-4S | DNA:RNA, Mg | 28 November 2015 | [13] |
| 5F0S | 3.0 | p58(266–456) | 4Fe-4S | DNA:RNA, Mn | 28 November 2015 | [13] |
| 5IUD | 3.3 | p180(338–1255) | DNA:DNA | 17 March 2016 | [20] |
a Mutations Lys-72-Ala and Met-73-Ala; b N-terminus of p58 is fused to the primase-binding peptide of p180 via a 15 amino acid linker; c Residues 360–379 and 409–420 are deleted; d Mutation Val-516-Ala; e Mutation Tyr-347-Phe.