Figure 3.

T cell targets for immunoregulatory therapy using antibodies. In addition to specific antigen recognition through the TCR, T-cell activation is regulated through a balance of positive and negative signals provided by co-stimulatory receptors. These surface proteins are typically members of either the TNF receptor or B7 superfamilies. Agonistic antibodies directed against activating co-stimulatory molecules and blocking antibodies against negative co-stimulatory molecules might enhance T-cell stimulation to promote tumor destruction. Reprinted with permission from NPG [109].