Figure 6. Modulation of microglial neurotoxicity by AgNP treatment.

N9 microglia were treated for 1 hr (pulse) with AgNP (50 μg/mL) and/or LPS (500 ng/mL), followed by a 24 hrs chase period with only LPS present. The medium was then transferred to N27 neurons and incubated for 48 hrs, after which time-point cell viability was assessed through an LDH release assay. Data is presented as mean ± SEM of three independent experiments; * and *** indicate p < 0.05, 0.005, respectively, vs. corresponding groups, as assessed by a one-way ANOVA with Tukey’s post-hoc test.