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. 2017 Mar 2;7:43679. doi: 10.1038/srep43679

Figure 1. The effects of the ARs on recombinant SIRT1.

Figure 1

(a) The time course of SIRT1 deacetylation activity of ARs. ARs and SRT1720 were assessed at 10 μM, and sirtinol was assessed at 100 μM by recombinant SIRT1 with 25 μM of NAD+. All values are the mean of three determinations. (b) The dose-dependency of olivetol for SIRT1 activity with 100 μM of NAD+ (±standard error [s.e.]) at 1000 sec. All values are the mean of at least four determinations. (c) The rate of the increase of SIRT1 activation with native p53 peptide monitored by the HPLC assay and CycLex assay at 1000 sec. All values are the mean of three determinations. Errors = s.e. *p < 0.05, **p < 0.01, compared with the control.