Table 1. Results of the lifespan trials of D. melanogaster adult males and females.

Trial	Genotype	Diet	Treatment	Females
				N(0)	Median lifespan		Mean lifespan		Log-rank test
					days	% change†	days	s.e.	χ 2	p-value
1	w1118	SF	Control	173	45		45.2	1.20
			Resveratrol	173	49	0.9	48.7	1.44	9.53	0.0020
			ARs	173	57	26.7	55.0	1.29	36.7	<0.0001
2	SIR2 hypomorphism	SF	Control	102	65		59.8	1.74
	dSir2 [17]/KG00871		Resveratrol	38	60	−0.83	58.2	1.80	8.51	0.0035
			ARs	42	60	−0.83	52.7	3.71	0.25	0.62
1	w1118	SF	Control	250	47		44.6	0.92
			Resveratrol	230	57.5	22.3	53.1	1.15	87.0	<0.0001
			ARs	250	57.5	22.3	54.4	0.90	92.1	<0.0001
2	SIR2 hypomorphism	SF	Control	154	57		52.9	1.22
	dSir2 [17]/KG00871		Resveratrol	40	53	0.75	50.5	1.83	10.1	0.0015
			ARs	113	57	0.0	54.3	1.42	1.09	0.30

^†The percent change is relative to the control. Bold: increase in lifespan at p < 0.01. Italics: decrease in lifespan at p < 0.01. SF: standard food (see Methods).