Table 1. PF-46396-resistant mutations generated in this study and their conservation status among HIV-1 clades.
| CA-CTD mutations | Conservation of residues (% frequency)# | SP1 mutations | Conservation of residues (% frequency)# |
|---|---|---|---|
| G156E | 99.75 | A1V* | 99.72 |
| P157S | 99.97 | A3V | 99.89 |
| P160L | 99.97 | A3T | 99.89 |
| I201V | 99.66 | ||
| G225D | 49.30 | ||
| H226Y | 99.86 |
*SP1: A1V mutation was not selected in the presence of PF-46396.
#Amino acid percentage frequency by position derived from the curated Los Alamos HIV-1 sequence database (3556 sequences of HIV-1 Major subtypes only).