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. 2017 Feb 24;8:14577. doi: 10.1038/ncomms14577

Figure 1. Generation of a mouse model that lacks Keap1 throughout the whole body and Nrf2 in the squamous epithelium.

Figure 1

(a) Relative Nqo1 gene expression level compared with Hprt expression in the oesophagus, skin, liver, lung, kidney and heart of mice at 10 days of age. Data are the means±s.e. (n=4). (*P<0.05 compared with Keap1−/−::Nrf2Flox/Flox, unpaired t-test) (b–e) Representative images of haematoxylin and eosin staining of transverse sections of the oesophagus from mice at 10 days of age (n=3). Scale bar, 100 μm. (f) Survival curve for control (n=56), Keap1−/−::Nrf2Flox/Flox (n=29) and NEKO (n=42) mice. (g) Growth curve for control (n=15), NEKO (n=10) and Keap1−/−::Nrf2Flox/Flox (n=16) mice. Data are the means±s.e.