Figure 5. NEKO mice have a defect in response to dehydration and vasopressin.

(a–c) Blood sodium (a), potassium (b) and chloride (c) in control and NEKO mice at 8–12 weeks of age after 24 h of water deprivation. Data are the means±s.e. (n=4) (**P<0.01, unpaired t-test). (d) Urine osmolality of NEKO mice at 8–12 weeks of age after 24 h of water deprivation. (**P<0.01, unpaired t-test) (e) dDAVP stimulation test of control and NEKO mice at 8–12 weeks of age after water loading. Mice were given water containing 5% sucrose before the experiment to ensure production of dilute urine. Urine was collected and 1 ng g⁻¹ body weight of dDAVP was i.p. injected. Urine osmolality was measured at 1 and 2 h after the injection. (**P<0.01, unpaired t-test).