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. 2017 Mar 2;7:43509. doi: 10.1038/srep43509

Figure 6. Expression of retinal vein occlusion-related genes in the RVO model.

Figure 6

The expression of RVO-related and inflammatory genes were evaluated by real-time PCR analysis 0.5 (12 h), 1, 3, and 7 days after occlusion and in untreated mice. (A) The expression level of Vegfa mRNA was significantly increased 12 h after occlusion, but unchanged compared to untreated mice after 3 and 7 days. (B) The expression level of Il6 mRNA was remarkably increased 12 h after occlusion. On days 1, 3 and 7, there was no statistically significant difference in expression levels compared to untreated controls. (C) The expression level of Icam1 mRNA was significantly augmented on days 1, 3, and 7. (D) The expression level of Mcp-1 was remarkably increased, to approximately 260 times that of untreated controls. Twelve hours after photocoagulation, the difference was not statistically significant. (E) The expression level of Pdgfa mRNA was increased to three times or more that of untreated mice. (F) The expression level of Aqp4 was decreased on day 1; however, it was increased to approximately five times that of untreated mice by day 7. Data are expressed as means ± S.E.M. (n = 3–5). ##P < 0.01, #P < 0.05 vs. Normal (Student’s t-test).