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. 2017 Jan 3;11(2):1142–1164. doi: 10.1021/acsnano.6b05737

Figure 3.

Figure 3

Methods for constructing RNA nanoparticles. (A-i) RNA nanoparticles constructed based on pRNA-3WJ from bacteriophage phi29. Adapted from ref (59). Reprinted with permission from ref (21) (copyright 2014 Oxford University Press) and ref (126) (copyright 2015 Elsevier). (A-ii) Cryo-EM reconstruction of RNA tetrahedron nanoparticles and RNA nanoprisms based on the pRNA-3WJ motif. Reprinted with permission from refs (18) and (125). Copyright 2016 Wiley Publishing. (B) Tectonics method to construct RNA nanosquares, polyhedron from tRNA, and nanoprisms from phi29 pRNA. Reprinted with permission from ref (103) (copyright 2009 American Chemical Society), ref (109) (copyright 2010 Nature Publishing Group), and ref (110) (copyright 2015 Nature Publishing Group). (C) Computational approaches to expedite RNA nanoparticle manufacture and optimization. Adapted from ref (116) and printed with permission from ref (117). Copyright 2010 Nature Publishing Group.