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. 2017 Jan 3;11(2):1142–1164. doi: 10.1021/acsnano.6b05737

Figure 5.

Figure 5

RNA nanoparticles for therapy. (A) RNA aptamers and chemical ligands are used to specifically target tumors in vivo without accumulation in healthy organs, targeting glioblastoma,63 breast cancer,60 gastric cancer,61 prostate cancer,152 colorectal cancer,62 and head and neck cancer.59 Adapted with permission from indicated references. (B) Targeting colorectal cancer metastasis utilizing RNA nanoparticles. Adapted from ref (62). Copyright 2015 American Chemical Society. (C) Ribozymes for cleaving specific RNA substrates similar to RNAi. Adapted with permission from ref (35). Copyright 2011 Nature Publishing Group. (D) Riboswitches to regulate gene expression. Reprinted with permission from ref (175). Copyright 2009 Elsevier. (E) Thermodynamic properties of nucleic acids used for activation and reagent release. Reprinted from (E-i) ref (181) (copyright 2013 Nature Publishing Group) and (E-ii) ref (180) (copyright 2014 American Chemical Society).