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. 2017 Jan 3;11(2):1142–1164. doi: 10.1021/acsnano.6b05737

Figure 6.

Figure 6

RNA nanoparticles for RNAi. (A) pRNA-3WJ to deliver BRCAA1 siRNA in vivo and inhibit the growth of gastric tumors. Adapted with permission from ref (61). Copyright 2015 Nature Publishing Group. (B) RCT used to generate kilobase concatemeric RNA oligomers for a high payload delivery of multiple siRNA. Adapted with permission from ref (186). Copyright 2016 Wiley Publishing Group. (C) Multivalency of siRNA showing a synergistic effect on gene knockdown. Increasing the copy number of luciferase siRNA shows drastic decrease in luminescence units. Reprinted with permission from ref (36). Copyright 2012 Elsevier. (D) RNA nanorings to carry six siRNAs for different targets in HIV for gene knockdown. Adapted from ref (188). Copyright 2014 American Chemical Society. (E) pRNA-3WJ to deliver anti-miRNA, LNA, to slow the growth of tumors in triple negative breast cancer. Adapted from ref (60). Copyright 2015 American Chemical Society.