Table 2.
This table presents the baseline and adjusted AUCs from ROCs that were calculated from ranked order of drug coefficients from logistic regression models from each ADE and FDP combination. caus=“x CAUSES ADE”, pred=“x PREDISPOSES ADE”, tcoe=“DRUG TREATS x; x COEXISTS_WITH ADE”. Counts=number of positive/negative examples. AUCs in bold indicate that an adjusted model drug coefficient is higher than baseline.
| Complete Results | Constrained Results | ||||||
|---|---|---|---|---|---|---|---|
| ADE | FDP | Counts (+/-) | Baseline | Adjusted | Counts (+/-) | Baseline | Adjusted |
| AKI | caus | 24 / 64 | .584 | .5853 | 11 / 13 | .6573 | .6643 |
| pred | .584 | NA | NA | NA | |||
| tcoe | .6126 | 18 / 40 | .6972 | .6125 | |||
| ALI | caus | 81 / 37 | .5167 | .515 | 44 / 14 | .5536 | .5568 |
| pred | .5297 | 50 / 24 | .4992 | .4825 | |||
| tcoe | .492 | 58 / 25 | .509 | .5303 | |||
| GIB | caus | 24 / 67 | .653 | .6418 | 20 / 48 | .6073 | .5792 |
| pred | .699 | 20 / 49 | .5949 | .6571 | |||
| tcoe | .7189 | 20 / 50 | .5964 | .69 | |||
| AMI | caus | 36 / 66 | .5112 | .5158 | 24 / 41 | .6026 | .6148 |
| pred | .5196 | 30 / 47 | .5319 | .5574 | |||
| tcoe | .5032 | 27 / 45 | .5687 | .5835 | |||