[Figure 1].

The lagged drug coefficients for four drug-lab pairs are plotted, and statistically significant (95% CI does not include 0) coefficients are denoted with points on the line plots. Lag number 1 indicates the interpolated drug values immediately preceding each laboratory measurement, and lag number 30 indicates the interpolated drug value 30 points in sequence time preceding each laboratory measurement. Significance on the left of the plot indicates rapid effects, while significance on the right indicates slower effects. Amphotericin B is shown to increase creatinine and decrease Potassium, as expected [23,24]. Simvastatin is shown to increase Hemoglobin levels early on, and spironolactone is shown to decrease creatinine initially, then raise it. These latter effects are likely explained, at least in part, by health care processes.