. 2017 Feb 10;2016:779–788.

[Table 1].

Model performance^*

	Variables in model			lab,drug,context	lab,drug	lab,drug	lab,drug	lab,drug	drug	drug
	Extra variable in TS			inpatient	inpatient	none	none	none	none	none
	Differences			diffs	diffs	diffs	no diffs	diffs	diffs	no diffs
	Normalized			norm	norm	norm	norm	no norm	norm	norm
	Model type			Multivariate	Multivariate	Multivariate	Multivariate	Multivariate	Multivariate	Univariate
Drug	Lab	Expected	Citation	Multivariate	Multivariate	Multivariate	Multivariate	Multivariate	Multivariate	Univariate
amphotericinB	Hemoglobin			0+, 21-	0+,21-	0+,16-	1+, 3-	0+,14-	0+,4-	0+, 30-
amphotericinB	Total CK			0+, 5-	0+,5-	0+,8-	1+, 2-	0+,0-	0+,6-	0+, 30-
amphotericinB	creatinine	pos	[37]	22+, 0-	22+,0-	21+,0-	1+, 0-	0+,0-	19+,0-	26+, 0-
amphotericinB	potassium	neg	[38]	0+, 22-	0+,22-	0+,22-	1+, 0-	0+,20-	0+,10-	0+, 30-
ibuprofen	Hemoglobin	neg	[23]	28+, 0-	28+,0-	27+,0-	5+, 0-	0+,0-	13+,0-	30+, 0-
ibuprofen	Total CK			0+, 8-	0+,8-	0+,1-	0+, 2-	0+,0-	0+,0-	0+, 4-
ibuprofen	creatinine	pos	[39,40]	26+, 0-	26+,0-	30+,0-	2+, 0-	9+,0-	18+,0-	0+, 5-
ibuprofen	potassium	Possible pos	[39,40]	23+, 0-	24+,0-	23+,0-	7+, 0-	23+,0-	8+,0-	30+, 0-
simvastatin	Hemoglobin		[41]	1+, 0-	0+,2-	0+,0-	0+, 3-	0+,1-	0+,22-	5+, 0-
simvastatin	Total CK	pos	[42]	5+, 0-	8+,0-	8+,0-	2+, 1-	9+,0-	7+,0-	12+, 0-
simvastatin	creatinine			0+, 0-	0+,4-	0+,6-	0+, 0-	2+,0-	0+,7-	0+, 10-
simvastatin	potassium			0+, 0-	0+,7-	0+,11-	1+, 0-	0+,0-	0+,8-	18+, 0-
spironolactone	Hemoglobin			28+, 0-	27+,0-	28+,0-	2+, 2-	28+,0-	21+,0-	0+, 5-
spironolactone	Total CK			0+, 0-	0+,0-	0+,2-	0+, 1-	0+,0-	0+,0-	5+, 0-
spironolactone	creatinine	pos	[43]	23+, 0-	23+,0-	25+,0-	7+, 0-	2+,1-	27+,0-	21+, 1-
spironolactone	potassium	pos	[44]	28+, 0-	28+,0-	29+,0-	8+, 1-	27+,0-	27+,0-	30+, 0-
warfarin	Hemoglobin	neg	[23]	30+, 0-	30+,0-	30+,0-	10+, 3-	30+,0-	29+,0-	30+, 0-
warfarin	Total CK			0+, 4-	0+,5-	0+,16-	0+, 1-	0+,0-	1+,0-	1+, 14-
warfarin	creatinine			28+, 0-	27+,0-	29+,0-	7+, 1-	25+,1-	28+,0-	0+, 18-
warfarin	potassium			30+, 0-	30+,0-	30+,0-	8+, 2-	28+,0-	18+,0-	30+, 0-

^[*

Pairs show the number of statistically significant positive and negative lags (e.g., “2+,1-” implies two positive lags and one negative lag). Green implies predominantly positive association, red implies predominantly negative, and grey implies minimal (less than 3) or mixed.