Figure 3.

Comparison of power for common and rare disease in genetic association studies. Misclassified outcome* stands for high sensitivity and specificity (Sensitivity=0.84, specificity=0.96 for common diseases; sensitivity=0.857, specificity=0.997 for rare diseases). Misclassified outcome† stands for low sensitivity and specificity (Sensitivity=0.665, specificity=0.819 for common diseases; sensitivity=0.707, specificity=0.988 for rare diseases). MAF=0.2 for common variant and 0.03 for rare variant.