Table 1.
Pharmacokinetic parameters and bioavailability of oral formulations
| T1/2(α) (h) | T1/2(β) (h) | Tmax (h) | Cmax (ng/ml) | AUC(0−∞) (ng h/ml) | |
|---|---|---|---|---|---|
| Scu | 0.405 ± 0.055 | 1.885 ± 0.105 | 1.235 ± 0.025 | 128.533 ± 85.467 | 6.419 ± 1.051 |
| Chit-DC-Scu | 1.446 ± 0.136 | 2.434 ± 0.154 | 2.375 ± 0.095 | 196.653 ± 45.239* | 13.034 ± 1.135* |
| Chit-DC-VB12-Scu | 2.529 ± 0.064 | 2.720 ± 0.250 | 3.776 ± 0.198 | 213.666 ± 81.786* | 22.096 ± 2.064* |
Each data point represents mean ± SD, n = 6 for plasma pharmacokinetic parameters
AUC is for scutellarin in plasma
* Significantly different (P < 0.05) from Scu group