Table 1.
Alkynyl sterols |
Natural sterols |
|||||||
---|---|---|---|---|---|---|---|---|
a-Lan | a-Lath | a-7-DHC | a-Chol | Lan | Lath | 7-DHC | Chol | |
Control | 0.055±0.013 | n.d. | 0.051±0.017 | 0.660±0.085 | 0.021±0.003 | n.d. | 0.042±0.008 | 12.7±0.8 |
fibroblast | ||||||||
SLOS | 0.143±0.021 | n.d. | 0.657±0.096 | n.d. | 0.015±0.001 | 0.167±0.145 | 3.47±0.51 | 8.1±1.7 |
fibroblast | ||||||||
NPC | 0.090±0.05 | n.d. | 0.011±0.011 | 1.308±0.22 | 0.017±0.002 | 0.051±0.089 | 0.049±0.016 | 33.9±6.9 |
fibroblast |
nmol of sterol determined by HPLC-MS and GC per 106 cells. Data presented are averages determined from triplicate analyses. n.d., not detected.