Skip to main content
. 2017 Mar;47:64–75. doi: 10.1016/j.exphem.2016.11.003

Figure 4.

Figure 4

BCL-2 is highly expressed in many ALL patient samples, and Capture-C identifies an enhancer cluster at the 3′ end of the BCL-2 gene. (A) COG P9906 B-ALL patients (n = 207). Average expression of BCL-2 is higher in MRD+ than MRD–patients. Each point represents an individual patient. (B) A St. Jude ALL data set [37] was assessed for BCL-2 gene expression. Details of the data set are given under Methods. (C) CTCF ChIP-seq (top track, from K562 cells, encode track) compared with Capture-C (bottom track) using a capture probe designed to the BCL-2 promoter (dark red bar). The tracks indicate the region about 4 Mb on either side of BCL-2. (D) Blowup of red box region from (C), revealing that there is a major interaction cluster at the 3′ end of the BCL-2 gene associated with several CTCF ChIP-seq peaks.