Table 2. Effect of compounds on membrane bound ATP-dependent systems. (Mózsik, Jávor: Dig. Dis. Sci. 33:92-105, 1988; Mózsik, Nagy, Tárnok, Vizi: Acta Med. Acad. Sci. Hung. 36: 1-29, 1979) (with permission).
| Membrane-Bound ATP-Dependent (ATP-Splitting) Systems | |||
|---|---|---|---|
| Mg2+-Na+-K+-dependent ATPase | |||
| Compounds | Mg2+-dependent | Na+-K+-dependent | Adenylate cyclase |
| Acetylcholine | No effect | Stimulation | Inhibition |
| Atropine | No effect | Inhibition | Stimulation |
| cAMP | No effect | Inhibtion | No effect |
| AMP | Stimulation | Inhibition | No effect |
*P values are presented between intact (sham-operated) versus “surgical” and “chemical” vagotomized groups: ↑, increase; ↓, decrease. Abbreviations: 0, not significant; ↓↓, P < 0.01; ↑↑↑(↓↓↓): P < 0.001.