Table 2. Summary of results based on information given in product inserts.

Generic Name	Trade Name	Level of Evidence	Statement from the leaflet
Dactinomycin	Cosmegen	3	On intravenous administration of Cosmegen, extravasation may occur with or without an accompanying burning or stinging sensation, even if blood returns well on aspiration of the infusion needle. If any signs or symptoms of extravasation have occurred, the injection or infusion should be immediately terminated and restarted in another vein.
Diphtheria, Pertussis, Tetanus (DPT)	Infanrix	2	Do not administer this product subcutaneously or intravenously.
Tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine	Boostrix	2	Special care should be taken to prevent injection into a blood vessel.
Dacarbazine	DTIC-Dome	2	The calculated dose of the resulting solution is drawn into a syringe and administered only intravenously.
Erythromycin lactobionate	Erythrocin	2	Must be administered by continuous or intermittent intravenous infusion only. Due to the irritative properties of erythromycin, I.V. push is an unacceptable route of administration.
Hep B vaccine	Engerix-B	2	Do not inject intravenously or intradermally.
MMR	Priorix Vaccine	2	Your doctor/nurse will ensure that Priorix is not injected into the bloodstream.
Promethazine HCL	Phenergon	2	The preferred route of administration for phenergan injection is by deep IM injection. The proper IV administration of the product is well tolerated, but use of this route is not without some hazards. Not for SC administration.
Pneumococcal 7-valent conjugate Vaccine	Prevnar	1	For intramuscular injection only. Do not inject intravenously. After insertion of the needle, aspirate and wait to see if any blood appears in the syringe, which will help avoid inadvertent injection into a vessel. If blood appears, withdraw the needle and prepare for injection at another site.
Progesterone injection	Progesterone	2	For intramuscular use only.
Flupenthixol	Fluanxol	2	Flupenthixol is administered by deep i.m. injection, preferably in the gluteus maximus. Flupenthixol is NOT for i.v. use.
Immune globulin (Human), I.V.	Gamimune ®	2	For intramuscular use only.
Bupivacaine HCl	Sensorcaine	1	It is essential that aspiration for blood or cerebrospinal fluid (where applicable) be done prior to injecting any local anesthetic, both the original dose and all subsequent doses, to avoid intravascular or subarachnoid injection. However, a negative aspiration does not ensure against an intravascular or subarachnoid injection.
Thiopental Sodium	Pentothal	2	The drug is prepared as a sterile powder and after reconstitution with an appropriate diluent is administered by the intravenous route. Pentothal is administered by the intravenous route only.
Diazepam	Valium Injection	2	For dosage in pediatric patients > 30 days old, see the specific indications below. When intravenous use is indicated, facilities for respiratory assistance should be readily available. Intramuscular: Valium Injection should be injected deeply into the muscle. Intravenous Use: (See warnings and precautions: Pediatric Use.) The solution should be injected slowly, taking at least 1 minute for each 5 mg (1 mL) given. Do not use small veins, such as those on the dorsum of the hand or wrist. Care should be taken to avoid intraarterial administration or extravasation.
Typhoid Vi Polysaccharide vaccine Typhim Vi	Typhim	2	For intramuscular use only. Do NOT inject intravenously.
Purified inactivated rabies vaccine	Verorab	2	Do not inject intravascularly.
Lidocaine	Xylocaine	1 & 3	It is essential that aspiration for blood or cerebrospinal fluid (where applicable) be done prior to injecting any local anesthetics, both the original and all subsequent doses, to avoid intravascular or subarachnoid injection. However, a negative aspiration does not ensure against an intravascular or subarachnoid injection. Local anesthetic solutions containing antimicrobial preservatives (e.g. methylparaben) should not be used for epidural or spinal anesthesia because the safety of these agents has not been established with regards to intrathecal injection, either intentional or accidental.
Rho (D) Immunoglobin (Human)	RHO	2	Do not inject Intravenously. Do not inject neonate.