Table 4. The cytotoxicity (expressed as IC 50, μM/mL) of tested compounds in HeLa and KCL-22 cells.
| Cells lines | L-tryptophan Schiff bases and their copper(II) complexes | |||||
|---|---|---|---|---|---|---|
| 2pyr.Trp | 3pyr.Trp | 4pyr.Trp | Cu-2pyr.Trp | Cu-3pyr.Trp | Cu-4pyr.Trp | |
| HeLa | > 1000 | > 1000 | > 1000 | 7±1.7 | 500±5.6 | 10±5 |
| KCL-22 | 56±9.1 | > 1000 | 100±6.5 | 80±7.5 | >1000 | 30±3.8 |
| LD 50, mg /kg (extrapolated) | >4000 | >5000 | >5000 | >2000 | >5000 | >2000 |
| Toxicity classification | Class III
Slightly toxic |
Class IV
Non-toxic |
Class IV
Non-toxic |
Class III
Slightly toxic |
Class IV
Non-toxic |
Class III
Slightly toxic |