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. 2017 Mar 2;7:43614. doi: 10.1038/srep43614

Table 2. Association between genetic variants and serum urate/gout in gender subgroup.

Gender SNP Gene A1 A2 Serum Urate Gout vs. HUA Gout vs. Control Gout vs. H + C
β P PFDR OR P PFDR OR P PFDR OR P PFDR
Male rs1051921 MLXIPL A G −6.276 0.061 0.188 1.01 0.950 1.000 0.90 0.374 0.609 0.93 0.587 0.728
  rs1061622 TNFRSF1B G T −2.498 0.416 0.644 1.03 0.773 0.887 1.03 0.723 0.862 1.03 0.700 0.780
  rs10749127 TCF7L2 T C −5.175 0.045 0.156 1.18 0.057 0.220 1.01 0.877 0.971 1.06 0.405 0.634
  rs10821905 A1CF A G 10.908 0.071 0.200 1.61 3.41E-03 0.053 1.69 3.98E-04 2.06E-03 1.64 4.02E-04 3.12E-03
  rs11231825 SLC22A12 C T −1.858 0.712 0.883 0.97 0.754 0.887 0.93 0.371 0.609 0.94 0.455 0.641
  rs1137070 MAOA C T −0.796 0.712 0.883 1.11 0.161 0.367 1.11 0.142 0.294 1.11 0.128 0.296
  rs11602903 SLC22A12 T A −1.118 0.907 0.965 0.96 0.687 0.852 0.93 0.439 0.648 0.94 0.478 0.645
  rs1178947 FZD9 C T −2.784 0.332 0.587 1.00 1.000 1.000 0.95 0.699 0.862 0.96 0.789 0.815
  rs12129861 PDZK1 A G −3.914 0.140 0.333 0.90 0.294 0.536 0.83 0.044 0.124 0.85 0.075 0.194
  rs12273892 NRXN2 T A 2.500 0.567 0.798 1.00 1.000 1.000 1.09 0.376 0.609 1.05 0.523 0.676
  rs1260326 GCKR T C 9.271 1.11E-04 8.59E-04 1.06 0.439 0.680 1.27 7.36E-04 3.26E-03 1.19 8.78E-03 0.034
  rs1481012 ABCG2 G A 25.859 1.57E-24 4.87E-23 1.69 4.99E-12 1.55E-10 2.70 9.66E-44 2.99E-42 2.27 1.07E-33 3.32E-32
  rs16890979 SLC2A9 T C −14.915 0.084 0.216 0.44 0.042 0.220 0.40 0.020 0.068 0.41 0.018 0.055
  rs2027432 NLRP3 A G −4.867 0.244 0.474 1.27 0.117 0.367 1.08 0.598 0.843 1.14 0.330 0.602
  rs2070803 TRIM46 A G 6.827 0.039 0.152 1.06 0.498 0.726 1.16 0.075 0.194 1.12 0.142 0.296
  rs2231137 ABCG2 T C −17.783 1.45E-11 2.25E-10 0.87 0.139 0.367 0.63 6.18E-09 9.58E-08 0.69 4.26E-06 6.60E-05
  rs231253 ALPK1 C G −1.484 0.353 0.587 1.08 0.389 0.634 1.01 0.938 1.000 1.03 0.704 0.780
  rs2941484 HNF4G T C 9.156 3.07E-04 1.90E-03 1.10 0.253 0.491 1.35 3.26E-05 2.86E-04 1.27 1.06E-03 6.59E-03
  rs3184504 SH2B3 T C 10.386 0.794 0.890 0.52 0.515 0.726 0.74 1.000 1.000 0.65 0.758 0.810
  rs3799352 SLC17A1 C T −8.894 3.09E-03 0.016 0.79 0.032 0.220 0.67 3.69E-05 2.86E-04 0.71 2.90E-04 2.99E-03
  rs4971101 TRIM46 G A 6.650 0.030 0.132 1.19 0.049 0.220 1.30 1.35E-03 5.23E-03 1.27 3.02E-03 0.016
  rs4994 ADRB3 G A 1.839 0.559 0.798 0.81 0.055 0.220 0.85 0.126 0.294 0.84 0.074 0.194
  rs505802 SLC22A12 T C −1.471 0.804 0.890 0.96 0.655 0.846 0.93 0.393 0.609 0.93 0.455 0.641
  rs5438 SLC2A5 T C −0.187 0.965 0.965 1.22 0.146 0.367 1.15 0.259 0.501 1.18 0.177 0.343
  rs5953210 MAOA A G −0.184 0.965 0.965 1.10 0.239 0.491 1.11 0.139 0.294 1.11 0.143 0.296
  rs712221 ESR1 A T −3.570 0.185 0.410 1.00 1.000 1.000 1.00 0.972 1.000 1.00 0.973 0.973
  rs738409 PNPLA3 G C −0.571 0.798 0.890 1.05 0.552 0.744 1.02 0.800 0.918 1.03 0.674 0.780
  rs742132 LRRC16A G A −2.715 0.209 0.432 1.14 0.166 0.367 1.03 0.686 0.862 1.06 0.409 0.634
  rs7512998 NLRP3 C T −1.459 0.594 0.801 1.22 0.164 0.367 1.06 0.650 0.862 1.11 0.407 0.634
  rs780094 GCKR T C 9.331 8.68E-05 8.59E-04 1.08 0.354 0.610 1.28 3.92E-04 2.06E-03 1.20 5.35E-03 0.024
  rs9358890 SLC17A4 G A −2.525 0.360 0.587 1.23 6.77E-03 0.070 1.18 0.025 0.078 1.19 0.010 0.035
Female rs1051921 MLXIPL A G 2.018 0.512 0.755 0.96 1.000 1.000 1.01 1.000 1.000 1.00 1.000 1.000
  rs1061622 TNFRSF1B G T 1.012 0.938 0.949 1.08 0.858 1.000 1.18 0.593 0.973 1.14 0.721 1.000
  rs10749127 TCF7L2 T C −13.689 8.02E-03 0.062 0.72 0.501 1.000 0.59 0.161 0.776 0.63 0.210 0.887
  rs10821905 A1CF A G 9.054 0.234 0.604 1.09 0.754 1.000 1.33 0.499 0.973 1.25 0.733 1.000
  rs11231825 SLC22A12 C T −4.161 0.427 0.661 0.71 0.489 1.000 0.63 0.254 0.876 0.65 0.257 0.887
  rs1137070 MAOA C T 0.746 0.949 0.949 0.98 1.000 1.000 1.06 0.886 1.000 1.04 0.887 1.000
  rs11602903 SLC22A12 T A −4.131 0.424 0.661 0.91 0.865 1.000 0.80 0.626 0.973 0.83 0.744 1.000
  rs1178947 FZD9 C T 3.361 0.409 0.661 0.96 1.000 1.000 1.00 1.000 1.000 0.99 1.000 1.000
  rs12129861 PDZK1 A G −8.623 0.107 0.367 1.19 0.594 1.000 1.18 0.602 0.973 1.18 0.602 1.000
  rs12273892 NRXN2 T A 8.449 0.232 0.604 0.68 0.378 1.000 0.78 0.593 0.973 0.75 0.595 1.000
  rs1260326 GCKR T C 5.820 0.280 0.661 1.04 1.000 1.000 1.15 0.673 0.994 1.12 0.779 1.000
  rs1481012 ABCG2 G A 30.660 2.41E-11 7.47E-10 1.32 0.386 1.000 2.22 6.57E-03 0.180 1.92 0.028 0.432
  rs16890979 SLC2A9 T C −46.523 7.56E-03 0.062 0.63 1.000 1.000 0.13 1.000 1.000 0.16 1.000 1.000
  rs2027432 NLRP3 A G 5.824 0.943 0.949 0.23 0.167 1.000 0.24 0.175 0.776 0.24 0.178 0.887
  rs2070803 TRIM46 A G 10.988 0.021 0.110 1.45 0.239 1.000 1.92 0.047 0.487 1.75 0.079 0.809
  rs2231137 ABCG2 T C −11.273 4.71E-03 0.062 0.91 0.868 1.000 0.74 0.434 0.973 0.78 0.529 1.000
  rs231253 ALPK1 C G 5.770 0.186 0.577 0.80 0.634 1.000 0.93 1.000 1.000 0.89 0.875 1.000
  rs2941484 HNF4G T C 2.492 0.727 0.939 1.59 0.133 1.000 1.64 0.103 0.776 1.61 0.104 0.809
  rs3184504 SH2B3 T C 8.782 0.936 0.949 0.42 1.000 1.000 0.47 1.000 1.000 0.46 1.000 1.000
  rs3799352 SLC17A1 C T −6.267 0.568 0.800 1.08 0.858 1.000 1.19 0.589 0.973 1.15 0.720 1.000
  rs4971101 TRIM46 G A 10.475 0.046 0.178 1.75 0.065 1.000 2.22 0.012 0.180 2.08 0.015 0.432
  rs4994 ADRB3 G A −0.013 0.720 0.939 0.52 0.241 1.000 0.49 0.142 0.776 0.50 0.193 0.887
  rs505802 SLC22A12 T C −4.249 0.384 0.661 0.70 0.394 1.000 0.62 0.254 0.876 0.64 0.257 0.887
  rs5438 SLC2A5 T C −5.789 0.763 0.939 0.83 1.000 1.000 0.83 1.000 1.000 0.83 1.000 1.000
  rs5953210 MAOA A G 1.592 0.937 0.949 0.74 0.377 1.000 0.79 0.472 0.973 0.78 0.472 1.000
  rs712221 ESR1 A T −8.678 0.031 0.135 1.11 0.774 1.000 1.00 1.000 1.000 1.03 1.000 1.000
  rs738409 PNPLA3 G C −3.785 0.390 0.661 1.35 0.300 1.000 1.25 0.471 0.973 1.28 0.390 1.000
  rs742132 LRRC16A G A −3.901 0.421 0.661 1.25 0.505 1.000 1.19 0.628 0.973 1.20 0.521 1.000
  rs7512998 NLRP3 C T 7.200 0.788 0.939 0.65 0.611 1.000 0.72 0.794 1.000 0.70 0.795 1.000
  rs780094 GCKR T C 4.899 0.391 0.661 1.08 0.885 1.000 1.19 0.574 0.973 1.16 0.674 1.000
  rs9358890 SLC17A4 G A −8.295 0.015 0.090 1.15 0.665 1.000 0.94 0.889 1.000 1.00 1.000 1.000

A1, allele 1, effect allele. HUA, hyperuricemia. H + C, hyperuricemia plus control. β values for SNP in serum urate were calculated by linear regression adjusted age and gender. P values for SNP in serum urate were calculated by deviance analysis for linear regression adjusted age and gender. P values for SNP in hyperuricemia and gout were calculated by Fisher’s exact test in addition model. PFDR value for SNP was multiple corrected by FDR method. When PFDR < 0.05, it would be considered as significant and showed in bold.