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. 2017 Mar 2;7:43614. doi: 10.1038/srep43614

Table 3. Association between genetic variants and serum urate in subgroups of BMI and smoking status.

Subgroup SNP Gene A1 A2 Subgroup-1 Subgroup-2 Subgroup-3
β P PFDR β P PFDR β P PFDR
BMI rs1051921 MLXIPL A G −21.273 0.226 0.742 −3.176 0.711 0.764 −2.121 0.654 0.945
  rs1061622 TNFRSF1B G T −8.077 0.352 0.742 −6.133 0.104 0.232 0.848 0.712 0.945
  rs10749127 TCF7L2 T C −9.276 0.792 0.801 −8.278 0.010 0.029 −5.490 0.151 0.384
  rs10821905 A1CF A G 53.677 0.205 0.742 6.270 0.382 0.615 13.138 0.095 0.276
  rs11231825 SLC22A12 C T 17.830 0.518 0.742 −1.577 0.460 0.655 −2.765 0.777 0.945
  rs11602903 SLC22A12 T A 20.188 0.422 0.742 −0.828 0.622 0.751 −2.630 0.783 0.945
  rs1178947 FZD9 C T −19.382 0.258 0.742 0.629 0.648 0.751 0.349 0.932 0.979
  rs12129861 PDZK1 A G −4.730 0.607 0.742 −6.398 0.102 0.232 −6.280 0.051 0.165
  rs12273892 NRXN2 T A 36.272 0.036 0.645 0.199 0.959 0.959 4.312 0.349 0.674
  rs1260326 GCKR T C −2.982 0.616 0.742 10.384 7.02E-04 6.78E-03 6.992 0.021 0.075
  rs1481012 ABCG2 G A 30.979 0.129 0.645 27.344 1.28E-15 3.71E-14 26.300 1.86E-14 5.39E-13
  rs16890979 SLC2A9 T C 45.018 0.317 0.742 −38.983 3.46E-03 0.017 −20.530 0.205 0.458
  rs2027432 NLRP3 A G −11.539 0.661 0.742 2.878 0.699 0.764 −0.515 0.979 0.979
  rs2070803 TRIM46 A G −20.087 0.530 0.742 8.033 9.32E-03 0.029 10.507 4.09E-03 0.030
  rs2231137 ABCG2 T C −17.470 0.414 0.742 −16.036 2.74E-06 3.97E-05 −16.200 5.16E-06 7.48E-05
  rs231253 ALPK1 C G −35.160 0.049 0.645 −1.255 0.749 0.775 2.505 0.757 0.945
  rs2941484 HNF4G T C 22.048 0.121 0.645 4.576 0.236 0.457 8.990 0.013 0.056
  rs3184504 SH2B3 T C 132.372 0.133 0.645 −7.595 0.614 0.751 14.799 0.761 0.945
  rs3799352 SLC17A1 C T −24.382 0.096 0.645 −12.323 1.68E-03 0.010 −2.600 0.499 0.851
  rs4971101 TRIM46 G A −23.147 0.382 0.742 8.239 6.95E-03 0.025 11.396 1.87E-03 0.018
  rs4994 ADRB3 G A −6.443 0.723 0.777 3.831 0.421 0.642 −1.655 0.622 0.945
  rs505802 SLC22A12 T C 17.830 0.518 0.742 −1.472 0.474 0.655 −2.624 0.814 0.945
  rs5438 SLC2A5 T C −9.690 0.402 0.742 3.953 0.515 0.679 −5.313 0.159 0.384
  rs712221 ESR1 A T 9.627 0.573 0.742 −3.445 0.365 0.615 −7.648 0.013 0.056
  rs738409 PNPLA3 G C 3.422 0.801 0.801 −3.254 0.103 0.232 −2.183 0.398 0.721
  rs742132 LRRC16A G A −14.136 0.344 0.742 −9.919 1.77E-03 0.010 0.008 0.961 0.979
  rs7512998 NLRP3 C T −14.082 0.593 0.742 6.528 0.328 0.595 1.005 0.855 0.954
  rs780094 GCKR T C −4.266 0.528 0.742 8.753 5.08E-03 0.021 8.456 6.34E-03 0.037
  rs9358890 SLC17A4 G A −4.744 0.665 0.742 −4.400 0.182 0.377 −3.912 0.227 0.470
Smoke rs1051921 MLXIPL A G 5.971 0.549 0.944 −7.482 0.174 0.463 −4.676 0.896 0.980
  rs1061622 TNFRSF1B G T −0.779 0.861 0.944 −6.357 0.111 0.403 1.371 0.766 0.980
  rs10749127 TCF7L2 T C −2.329 0.665 0.944 −5.628 0.165 0.463 −7.566 0.017 0.072
  rs10821905 A1CF A G 22.615 0.047 0.227 7.961 0.358 0.606 9.987 0.230 0.477
  rs11231825 SLC22A12 C T 1.368 0.911 0.944 −4.284 0.279 0.539 −0.209 0.878 0.980
  rs11602903 SLC22A12 T A 1.298 0.906 0.944 −3.390 0.390 0.606 0.109 0.936 0.980
  rs1178947 FZD9 C T 11.793 0.211 0.510 −4.968 0.397 0.606 −4.150 0.978 0.980
  rs12129861 PDZK1 A G 5.309 0.676 0.944 −3.177 0.505 0.665 −5.869 0.062 0.157
  rs12273892 NRXN2 T A 6.981 0.130 0.449 −5.118 0.244 0.539 7.146 0.058 0.157
  rs1260326 GCKR T C 6.767 0.170 0.449 4.493 0.211 0.509 9.632 3.98E-04 2.88E-03
  rs1481012 ABCG2 G A 16.925 9.31E-04 0.027 15.645 3.97E-05 5.76E-04 26.700 6.69E-17 1.94E-15
  rs16890979 SLC2A9 T C 10.662 0.850 0.944 −32.004 0.013 0.094 −30.951 0.028 0.091
  rs2027432 NLRP3 A G 4.177 0.247 0.534 −1.521 0.873 0.974 −9.090 0.104 0.231
  rs2070803 TRIM46 A G 18.860 5.09E-03 0.053 0.240 0.916 0.975 7.541 8.22E-03 0.040
  rs2231137 ABCG2 T C −11.602 0.041 0.227 −15.777 2.36E-05 5.76E-04 −12.900 4.22E-05 6.12E-04
  rs231253 ALPK1 C G 1.271 0.572 0.944 2.679 0.432 0.627 −2.099 0.744 0.980
  rs2941484 HNF4G T C 1.411 0.865 0.944 11.394 2.08E-03 0.020 2.385 0.560 0.855
  rs3184504 SH2B3 T C 28.100 0.633 0.944 −0.371 0.975 0.975 16.018 0.501 0.807
  rs3799352 SLC17A1 C T −14.807 0.014 0.101 −7.875 0.078 0.403 −3.789 0.480 0.807
  rs4971101 TRIM46 G A 18.853 5.45E-03 0.053 0.930 0.781 0.944 7.705 7.91E-03 0.040
  rs4994 ADRB3 G A 1.523 0.855 0.944 2.642 0.661 0.833 5.882 0.271 0.496
  rs505802 SLC22A12 T C 1.746 0.961 0.961 −4.339 0.277 0.539 −0.451 0.778 0.980
  rs5438 SLC2A5 T C −6.393 0.909 0.944 −4.653 0.463 0.639 −0.205 0.913 0.980
  rs712221 ESR1 A T −5.993 0.164 0.449 −5.768 0.111 0.403 −6.085 0.065 0.157
  rs738409 PNPLA3 G C −1.163 0.837 0.944 −3.330 0.365 0.606 2.196 0.780 0.980
  rs742132 LRRC16A G A −7.178 0.258 0.534 −6.547 0.095 0.403 −0.708 0.980 0.980
  rs7512998 NLRP3 C T 6.811 0.129 0.449 −1.505 0.838 0.973 −6.488 0.274 0.496
  rs780094 GCKR T C 6.698 0.156 0.449 4.908 0.175 0.463 9.759 3.85E-04 2.88E-03
  rs9358890 SLC17A4 G A −0.331 0.891 0.944 −0.341 0.945 0.975 −5.700 0.027 0.091

A1, allele 1, effect allele. Subgroup of BMI: 1, Underweight (BMI < 18.5); 2, Normal (18.5 Inline graphic BMI < 25); 3, Overweight (BMI ≧ 25). Subgroup of smoke: 1, non-smokers; 2, former smokers; 3, current smokers. β values for SNP in serum urate were calculated by linear regression adjusted age and gender. P values for SNP in serum urate were calculated by deviance analysis for linear regression adjusted age and gender. PFDR value for SNP was multiple corrected by FDR method. When PFDR < 0.05, it would be considered as significant and showed in bold. Because of rs1137070 and rs5953210 in Chromosome X, they cannot be analyzed in this table.