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. 2017 Mar 2;7:43655. doi: 10.1038/srep43655

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Copyright © 2017, The Author(s)

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Panel a shows denudation of glomerular capillaries after 16 hours exposure to 5 mM MTZ of Chipper (Tg(fli1a:eGFP); Tg(nphs2:Eco.NfsB-mCherry); mitfa^w2/w2; roy^a9/a9) while control larvae showed uniform covering with mCherry positive podocytes (scale bar represents 10 μm). The phenotype in transmission electron micrographs of 4 dpf Cherry larvae after 24 hours MTZ treatment verified these findings (panel b), as broad areas of the GBM (arrowheads) were denuded, while control larvae showed normal morphology with foot processes and filtration slits. Endothelial cells of denuded areas showed significant fewer fenestrations (arrows). Note the higher contrasted Bowman’s space in 5 mM MTZ group compared to control caused by proteinaceous fluid due to leakiness of the glomerular filter (scale bar represents 1 μm, yellow = GBM, representative images from n = 3 experiments).