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. Author manuscript; available in PMC: 2017 Mar 2.
Published in final edited form as: Biochem J. 2015 Jun 29;470(2):181–193. doi: 10.1042/BJ20141494

Figure 1. 2-AGE induces ERRγ and CYP7A1 gene expression.

Figure 1

(A and B) AML12 cells were treated with 2-AGE (10 µM) for the indicated time period. (C and D) Rat primary hepatocytes were treated with 2-AGE (10 µM) for 12 h. ***P < 0.001. (E and F) HepG2 cells were treated with 2-AGE (10 µM) for 12 h. ***P < 0.001. ERRγ and CYP7A1 expression in (A–F) were analysed by qPCR and Western blot analysis. (G) Mouse primary hepatocytes isolated from WT and CB1−/− mice were treated with 2-AGE (10 µM) for 12 h. CYP7A1, ERRγ and CB1R gene expression were measured by qPCR analysis and normalized to actin expression. ***P < 0.001. All data are representative of at least three independent experiments. Error bars show ± S.E.M.